彭宗根，1975年生，中国医学科学院医药生物技术研究所研究员，博士生导师。1994年考入南昌大学微生物学专业，1998年获得学士学位。1998年在福建医科大学病原生物学专业攻读硕士学位，从事抗病毒性肝炎基础研究。2001年在中国协和医科大学微生物与生化专业攻读博士学位，从事抗病毒药物研究。2004年留所工作至今。2010年聘为副研究员，2013年聘为研究员。

抗病毒、抗肝炎药物药理学。以宿主因子为靶的抗病毒、抗非酒精性脂肪性肝炎药物的研发。

1. Wang Y#, Li J#, Tan J, Yang B, Quan Y, Peng Z*, Li Y*, Li Z. Design, Synthesis, and Biological Evaluation of 2-((4-Bisarylmethyl-piperazin-1-yl)methyl) benzonitrile Derivatives as HCV Entry Inhibitors. J Med Chem. 2022, 65(3):2107-2121. (IF=8.039)

2. Wang M, Li J, Li H, Dong, B, Jiang, J, Liu, N, Tan, J, Wang, X, Lei, L, Li, H, Sun, H, Tang, M, Wang, H, Yan, H, Li, Y, Jiang, J, Peng, Z*. Down-regulating the high level of 17-beta-hydroxysteroid dehydrogenase 13 plays a therapeutic role for non-alcoholic fatty liver disease. Int J Mol Sci, 2022, 23(10): 5544. (IF= 6.208)

3. Li H#, Liu NN#, Li JR, Dong B, Wang MX, Tan JL, Wang XK, Jiang J, Lei L, Li HY, Sun H, Jiang JD* and Peng ZG*. Combined Use of Bicyclol and Berberine Alleviates Mouse Nonalcoholic Fatty Liver Disease. Front Pharmacol. 2022, 13:843872. (IF=5.988)

4. Zou LL, Li JR, Li H, Tan JL, Wang MX, Liu NN, Gao RM, Yan HY, Wang XK, Dong B, Li YH, Peng ZG*. TGF-β isoforms inhibit hepatitis C virus propagation in transforming growth factor beta/SMAD protein signalling pathway dependent and independent manners. J Cell Mol Med. 2021, 25(7):3498-3510. (IF=5.295)

5. Jiang X#, Tan J#, Wang Y, Chen J, Li J, Jiang Z, Quan Y, Jin J, Li Y, Cen S, Li Y*, Peng Z*, Li Z*. 2-((4-Arylpiperazin-1-yl)methyl)

benzonitrile Derivatives as Orally Available Inhibitors of Hepatitis C Virus with a Novel Mechanism of Action. J Med Chem. 2020, 63(11):5972-5989. (IF=7.446)

6. Huang MH#, Li H#, Xue R, Li JR, Wang LH, ChengJJ, Wu ZY, Li WJ, Chen JH, Lv XQ, Li Q, Lan P, Zhao LM, Yang YF*, Peng ZG*, Jiang JD*. Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication. Acta Pharmaceutica Sinica B. 2019, 9(4):769-781. (IF=7.097)

7. Li H, Li JR, Huang MH, Chen JH, Lv XQ, Zou LL, Tan JL, Dong B, Peng ZG*, Jiang JD* . Bicyclol attenuates liver inflammation induced by infection of hepatitis C virus via repressing ROS-mediated activation of MAPKs/NF-κB signaling pathway. Front. Pharmacol. 2018, 9:1438. (IF=3.845, F1000)

8. Cheng JJ, Li JR, Huang MH, Ma LL, Wu ZY, Jiang CC, Li WJ, Li YH, Han YX, Li H, Chen JH, Wang YX, Song DQ, Peng ZG*, Jiang JD*. CD36 is a co-receptor for hepatitis C virus E1 protein attachment. Sci Rep. 2016, 6:21808. (IF=4.259)

9. Peng ZG#, Zhao ZY#, Li YP#, Wang YP, Hao LH, Fan B, Li YH, Wang YM, Shan YQ, Han YX, Li JR, You XF, Li ZR*, Jiang JD*. Host apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-Like 3G is an innate defensive factor and drug target against hepatitis C virus. Hepatology, 2011, 53(4): 1080-1089. (IF=12.003)

10. Peng ZG#, Fan B#, Du NN#, Wang YP, Gao LM, Li YH, Li YH, Liu F, You XF, Han YX, Zhao ZY, Cen S, Li JR, Song DQ*, Jiang JD*. Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA. Hepatology, 2010, 52(3): 845-53. (IF=11.665)