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医学实验动物研究所

个人简介

鲍琳琳,1979年生,籍贯内蒙古赤峰,动物学家,医学实验动物研究所研究员,博士生导师。1997年考入内蒙古医学院临床医学系儿科专业,2002年获得学士学位。2002年在中国协和医科大学病理学与病理生理学专业攻读硕士学位,从事感染性疾病动物模型研究。2012年在中国农业大学预防兽医学专业攻读博士学位,从事感染性疾病动物模型应用研究。2009年为助理研究员,2013年为副研究员,2019年为研究员。


主要研究方向

从事新发感染性疾病动物模型研制和比较医学研究。应用呼吸系统感染性疾病动物模型,进行从疾病机制、病原传播到疫苗和药物有效性全链条研究,保障了包括新冠攻关在内的多次疫情科研攻关。


代表性成果

1. Song Z#, Bao L#, Deng W#, Liu J#, Ren E#, Lv Q, Liu M, Qi F, Chen T, Deng R, Li F, Liu Y, Wei Q, Gao H, Yu P, Han Y, Zhao W, Zheng J, Liang X, Yang F*, Qin C*. Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients. Signal Transduct Target Ther 28;7(1):29. (IF=38.103)

2. Deng W#, Lv Q#, Li F#, Liu J#, Song Z#, Qi F, Wei Q, Yu P, Liu M, Zhou S, Zhang Y, Gao H, Wang N, Jia Z, Gao K, Liu J, Xiao C, Shang H, Wang X, Bao L*, Qin C*. Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques. Signal Transduct Target Ther 18;7(1):124. (IF=38.103)

3. Wang K#, Jia Z#, Bao L#, Wang L#, Cao L#, Chi H#, Hu Y#, Li Q#, Zhou Y#, Jiang Y, Zhu Q, Deng Y, Liu P, Wang N, Wang L, Liu M, Li Y, Zhu B, Fan K, Fu W, Yang P, Pei X, Cui Z, Qin L, Ge P, Wu J, Liu S, Chen Y, Huang W, Wang Q*, Qin CF*, Wang Y*, Qin C*, Wang X*. Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants. Nature 603(7903):919-925. (IF=69.503)

4. Bao L#, Deng W#, Qi F#, Lv Q#, Song Z#, Liu J, Gao H, Wei Q, Yu P, Xu Y, Qu Y, Li F, Xue J, Gong S, Liu M, Wang G, Wang S, Zhao B, Cong B*, Qin C*. Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza. Signal Transduct Target Ther 20;6(1):200. (IF=18.187)

5. Deng W#, Bao L#, Gao H#, Xiang Z#, Qu Y#, Song Z#, Gong S, Liu J, Liu J, Yu P, Qi F, Xu Y, Li F, Xiao C, Lv Q, Xue J, Wei Q, Liu M, Wang G, Wang S, Yu H, Chen T, Liu X, Zhao W, Han Y, Qin C*. Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques. Nat Commun 2;11(1):4400. (IF=14.919)

6. Yang J#, Wang W#, Chen Z#, Lu S#, Yang F#, Bi Z#, Bao L#, Mo F, Li X, Huang Y, Hong W, Yang Y, Zhao Y, Ye F, Lin S, Deng W, Chen H, Lei H, Zhang Z, Luo M, Gao H, Zheng Y, Gong Y, Jiang X, Xu Y, Lv Q, Li D, Wang M, Li F, Wang S, Wang G, Yu P, Qu Y, Yang L, Deng H, Tong A, Li J, Wang Z, Yang J, Shen G, Zhao Z, Li Y, Luo J, Liu H, Yu W, Yang M, Xu J, Wang J, Li H, Wang H, Kuang D, Lin P, Hu Z, Guo W, Cheng W, He Y, Song X, Chen C, Xue Z, Yao S, Chen L, Ma X, Chen S, Gou M, Huang W, Wang Y, Fan C, Tian Z, Shi M, Wang FS, Dai L, Wu M, Li G, Wang G, Peng Y, Qian Z, Huang C, Lau JY, Yang Z, Wei Y, Cen X, Peng X, Qin C, Zhang K*, Lu G*, Wei X*. A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity. Nature 586(7830):572-577. (IF=49.962, C100)

7. Deng W#, Bao L#, Liu J#, Xiao C#, Liu J#, Xue J#, Lv Q3, Qi F, Gao H, Yu P, Xu Y, Qu Y, Li F, Xiang Z, Yu H, Gong S, Liu M, Wang G, Wang S, Song Z, Liu Y, Zhao W, Han Y, Zhao L, Liu X, Wei Q, Qin C*. Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques. Science 14;369(6505):818-823. (IF=47.728, C100, ESI)

8. Cao Y#, Su B#, Guo X#, Sun W#, Deng Y#, Bao L#, Zhu Q#, Zhang X, Zheng Y, Geng C, Chai X, He R, Li X, Lv Q, Zhu H, Deng W, Xu Y, Wang Y, Qiao L, Tan Y, Song L, Wang G, Du X, Gao N, Liu J, Xiao J, Su XD, Du Z, Feng Y, Qin C*, Qin C*, Jin R*, Xie XS*. Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells. Cell 9;182(1):73-84.e16. (IF=41.584, C100, ESI)

9. Bao L#, Deng W#, Huang B#, Gao H#, Liu J#, Ren L, Wei Q, Yu P, Xu Y, Qi F, Qu Y, Li F, Lv Q, Wang W, Xue J, Gong S, Liu M, Wang G, Wang S, Song Z, Zhao L, Liu P, Zhao L, Ye F, Wang H, Zhou W, Zhu N, Zhen W, Yu H, Zhang X, Guo L, Chen L, Wang C, Wang Y, Wang X, Xiao Y, Sun Q, Liu H, Zhu F, Ma C, Yan L, Yang M, Han J, Xu W, Tan W, Peng X, Jin Q, Wu G*, Qin C*. The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. Nature 583(7818):830-833. (IF=42.778, C100, ESI)

10. Gao Q#, Bao L#, Mao H#, Wang L#, Xu K#, Yang M#, Li Y, Zhu L, Wang N, Lv Z, Gao H, Ge X, Kan B, Hu Y, Liu J, Cai F, Jiang D, Yin Y, Qin C, Li J, Gong X, Lou X, Shi W, Wu D, Zhang H, Zhu L, Deng W, Li Y, Lu J*, Li C*, Wang X*, Yin W*, Zhang Y*, Qin C*. Development of an inactivated vaccine candidate for SARS-CoV-2. Science 3;369(6499):77-81. (IF=41.845, C100, ESI)