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药物研究所

个人简介

张金兰,1969年生,籍贯内蒙古呼和浩特,药物分析学家,药物研究所研究员,博士生导师。1987年考入北京医科大学药学专业,1992年获得学士学位。1992年在中国协和医科大学药物分析专业攻读硕士学位,从事中药成分分离和分析研究。1999年在中国协和医科大学药物分析专业攻读博士学位,从事中草药代谢产物分析研究。2002年进入北京大学医学部进行博士后研究工作,主要研究中草药成分分析和体内代谢研究。 1998年升为助理研究员。2000年破格升为副研究员,2007年聘任为研究员。


主要研究方向

聚焦药物分析新技术及方法研究与应用。构建基于色谱质谱联用和多维数据分析的药物分析关键技术平台,重点解决药物关键质量属性和体内分析技术瓶颈,支撑药物质量分析、药代动力学研究和药效评价。


代表性成果

1. Jin-Lan Zhang#, Yu-Huan Li#, Lu-Lu Wang#, Hong-Qi Liu#, Shuai-Yao Lu#, Yong Liu, Ke Li, Bin Liu, Su-Yun Li, Feng-Min Shao, Kun Wang, Ning Sheng, Rui Li, Jin-Jin Cui, Pei-Chun Sun, Chun-Xia Ma, Bo Zhu, Zhe Wang, Yuan-Hao Wan, Shi-Shan Yu, Yongsheng Che, Chao-Yang Wang, Chen Wang, Qiangqian Zhang, Li-Min Zhao, Xiao-Zhong Peng*, Zhenshun Cheng*, Jun-Biao Chang* , Jian-Dong Jiang*, Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients,  Signal Transduction & Targeted Therapy, 2021, 6(1), 414. (IF=38.104)

2. Zhe Wang#, Fan Zhang#, Wei Liu, Ning Sheng, Hua Sun*, Jinlan Zhang*. Impaired tricarboxylic acid cycle flux and mitochondrial aerobic respiration during isoproterenol induced myocardial ischemia is rescued by bilobalide. Journal of Pharmaceutical Analysis,  2021, 11, 764-775. (IF=14.026)

3. Miao Lin#, Menglin Li#, Hao Zheng, Haidan Sun, Jinlan Zhang*. Lipoprotein proteome profile: novel insight into hyperlipidemia, Clinical and Translational Medicine.2021, doi=10.1002/ctm2.361.(IF=8.554)

4. Menglin Li#, Hao Zheng, Miao Lin, Wenwen Zhu, Jinlan Zhang*. Characterization of the protein and peptide of excipient zein by the multienzyme digestion coupled with nano-LC-MS/MS. Food Chemistry, 2020, 321: 126712. (IF=7.514)

5. Wenwen Zhu#, Menglin Li#, Jinlan Zhang*, Integrating Intact Mass Analysis and Middle-Down Mass Spectrometry Approaches to Effectively Characterize Trastuzumab and Adalimumab Structural Heterogeneity.  Journal of Proteome Research, 2020. doi=10.1021/acs.jproteome.0c00373. (IF=5.37)

6. Ning Sheng#, Hao Zheng#, Min Li, Menglin Li, Zhe Wang, Ying Peng, Haibo Yu*, Jinlan Zhang*. 4,5 caffeoylquinic acid and scutellarin, identified by integrated metabolomics and proteomics approach as the active ingredients of Dengzhan Shengmai, act against chronic cerebral hypoperfusion by regulating glutamatergic and GABAergic synapses. Pharmacological Research, 2020, 152C, 104636. (IF=7.658)

7. Miao Lin# , Xiong Chen# , Zhe Wang , Dongmei Wang*, Jinlan Zhang*, Global profiling and identification of bile acids by multi-dimensional data mining to reveal a way of eliminating abnormal bile acids. Analytica Chimica Acta, 10.1016/j.aca.2020.07.067. (IF=6.558)

8. Miao Lin #, Zhe Wang , Dongmei Wang, Xiong Chen, Jinlan Zhang*, A mathematical model-assisted UHPLC-MS/MS method for global profiling and quantification of cholesteryl esters in hyperlipidemic golden hamster.Analytical chemistry, 2019, 91, 4504–4512.(IF=6.785)

9. Hu T#, Jia ZX, Zhang JL.*, Strategy for Comprehensive Profiling and Identication of Acidic Glycosphingolipids Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry. Analytical chemistry, 2017, 89, 7808−7816.(IF=6.042)

10. Tie C#, Hu T#, Jia ZX, Zhang JL.*, Derivatization Strategy for the Comprehensive Characterization of Endogenous Fatty Aldehydes Using HPLC-Multiple Reaction Monitoring.  Analytical chemistry, 2016, 88,7762-7768.(IF=6.320)