彭英，1970年生，籍贯河北唐山，中国医学科学院药物研究所研究员，博士生导师。1989年考入河北医学院临床医学专业，1994年获得学士学位。1996年在华西医科大学药理学专业攻读硕士学位，从事药理学研究。2001年在协和医科大学大学药理学专业攻读博士学位，从事神经药理学研究。2004年进入哈佛大学医学院，Brigham and Women’s Hospital的神经疾病中心进行博士后研究工作，主要从事阿尔茨海默病发病机制研究。2008年回国进入药物研究所工作，2009年聘任为副研究员。2015年聘任为研究员。

脑疾病（急性缺血性脑卒中、脑外伤）的发病机制及创新药物研究。神经退行性疾病（阿尔茨海默病、肌萎缩性侧索硬化症）的发病机制及创新药物研究。精神疾病（焦虑症、抑郁症）的发病机制及创新药物研究。

1. Zhou Y#, Tang J, Lan J, Zhang Y, Wang HY, Chen QY, Kang Y, Sun Y, Feng X, Wu L, Jin HT*, Chen SZ* and Peng Y*.Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of Amyotrophic lateral sclerosis. Acta Pharmaceutica Sinica B. 2022, in press. (IF=14.911)

2. Tang J#, Kang Y, Zhou Y, Li X, Lan J, Wu L, Feng X*, and Peng Y*. ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis. Neurobiol Dis. 2021; 153:105315. (IF=7.046)

3. Huang LJ#, Lan JQ, Tang JS, Kang YY, Feng XH, Wu L, and Peng Y*. L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurites pathology in Alzheimer’s disease mouse model and cultured hippocampal neurons. Mol Neurobiol. 2021;58(3):1260-74. (IF=5.682)

4. Tang JS#, Kang YY, Huang LJ, Wu L, andPeng Y*. TIMP1 preserves the blood–brain barrier through interacting with CD63/integrin β1 complex and regulating downstream FAK/RhoA signaling. Acta Pharmaceutics Sinica B. 2020;10(6):987-1003.  (IF=11.614)

5. Huang L#, Zhang Y, Peng Y, Zhao Z, Zhou Y, Wang X*, and Peng Y*.Protective effect of potassium 2-(l-hydroxypentyl)-benzoate on hippocampal neurons, synapses and dystrophic axons in APP/PS1 mice. Psychopharmacology (Berl). 2019;236(9):2761-71. (IF= 3.13)

6. Zhao CY^#, Hou WZ, Lei H, Huang LJ, Wang S, Cui DD, Xiang CH, Wang XL*, and Peng Y*. Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice. Acta Pharmaceutica Sinica B. 2017;7(4):470-8.  (IF=6.014)

7. Li L^#, Xu SF, Liu LF, Feng RT, Gong YX, Zhao XY*, Li J, Cai J, Feng N, Wang L, Wang XL*, and Peng Y*. Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ_25-35-induced Rat Model of Alzheimer’s Disease. J Alzheimers Dis. 2017;56(4):1403-17. (IF=3.476)

8. Peng Y^#, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, and Lemere CA*. L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease. J Neurosci. 2010;30(24):8180-9. (IF=7.271, F1000, C100)

9. Maier M^#, Peng Y^#, Jiang L, Seabrook TJ, Carroll MC, and Lemere CA*. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J Neurosci. 2008;28(25):6333-41. (IF=7.452, C100)

10. Peng Y^#, Xu S, Chen G, Wang L, Feng Y, and Wang X*. L-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats. J Pharmacol Exp Ther. 2007;321(3):902-10. (IF=4.309, C100)