胡宽，男，1990年生，籍贯湖南，‬药物研究所研究员，博士生导师。2008年考入兰州大学核化工与核燃料工程专业，2012年获得学士学位。2012-2017年在北京大学化学基因组学专业攻读博士学位，从事稳定多肽药物研究。2017年07月-2018年03月在中国科学院北京纳米能源与系统研究所担任助理研究员；2018年04月-2021年03月在日本国立量子科学技术研究开发机构担任博士后研究员；2021年04月-2022年05月担任日本国立量研机构量子医科学研究所研究员。2022年06月加入中国医科学科学院北京协和医学院药物研究所。

以解决临床重大疾病（如恶性肿瘤）用药需求为目标开展创新药物研究。开发具有临床诊疗价值的多肽核药和BNCT药物；发展高通量筛选先导活性多肽方法；开发温和高效的生物正交方法用于生物活性分子的核素选择性标记。

1. Duo Wang#, Jun Zhou#, Weimin Fang, Zerong Chen, Meng Fan, Cuiqing Huang, Mingrong Zhang, Zeyu Xiao*, Kuan Hu*, Liangping Luo*. A multifunctional nanotheranostic agent potentiates Erlotinib to EGFR wild-type non-small cell lung cancer, Bioactive Materials 2022, 13, 312-323. (IF=16.874)

2.Kuan Hu#, Wenyu Wu#, Lin Xie, Hao Geng, Yiding Zhang, Masayuki Hanyu, Lulu Zhang, Yinghuan Liu, Kotaro Nagatsu, Hisashi Suzuki, Jialin Guo, Yun-Dong Wu*, Zigang Li*, Feng Wang*, Ming-Rong Zhang*, Whole-body PET tracking of a D-dodecapeptide and its Radiotheranostic Potential for PD-L1 Overexpressing Tumors. Acta Pharmaceutica Sinica B 2022, 12(3): 1363e1376. (IF=14.903)

3.Lin Xie#, Kuan Hu#, Yanhong Duo#, Takashi Shimokawa, Katsushi Kumata, Yiding Zhang, Cuiping Jiang, Lulu Zhang, Nobuki Nengaki, Hidekatsu Wakizaka, Yihai Cao*, Ming-Rong Zhang*, Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy, Journal for ImmunoTherapy of Cancer 2021, 9: e002616. (IF=9.118)

4.Kuan Hu#, Lin Xie, Yiding Zhang, Masayuki Hanyu, Zhimin Yang, Kotaro Nagatsu, Hisashi Suzuki, Jiang Ouyang, Xiaoyuan Ji, Junjie Wei, Hao Xu, Omid C. Farokhzad, Steven H. Liang*, Lu Wang*, Wei Tao* & Ming-Rong Zhang*. Nature communications 2020, 11 (1): 2778. (IF=12.117, ESI, C100)

5. Wei Xiong#, Kuan Hu#, Zhe Li#, Yixiang Jiang, Zigang Li*, Zhou Li*, Xinwei Wang*, A wearable system based on core-shell structured peptide-Co9S8 supercapacitor and triboelectric nanogenerator. Nano Energy 2019, 66, 104149. (IF=13.670)

6.Zhe Li#, Kuan Hu#, Mengyan Yang#, Yang Zou#, Jinbin Yang, Min Yu, Huaying Wang, Xuecheng Qu, Puchuan Tan, Chan Wang, Xuechang Zhou*, Zhou Li*, Elastic Cu@PPy sponge for hybrid device with energy conversion and storage. Nano Energy 2019, 58, 852-861. (IF=13.670)

7.Huaying Wang#, Kuan Hu#, Zhe Li#, Chan Wang, Min Yu, Zigang Li*, Zhou Li*, Black Phosphorus Nanosheets Passivation Using a Tripeptide. Small 2018, 14 (35), 1801701. (IF=8.852)

8.Kuan Hu#,*, Chao Zheng, Miao An, Xiaohui Ma*, Lu Wang*, A peptide-based supercapacitor and its performance improvement via TiO2 coating. Journal of Materials Chemistry A 2018, 6 (17), 8047-8052. (IF=9.020)

9.Kuan Hu#, Yixiang Jiang#, Wei Xiong, Hu Li, Pei-Yu Zhang, Feng Yin, Qianling Zhang, Hao Geng, Fan Jiang*, Zhou Li*, Xinwei Wang*, Zigang Li*, Tuning peptide self-assembly by an in-tether chiral center. Science Advances 2018, 4 (5), eaar5907. (IF=11.511)

10. Kuan Hu#, Hao Geng, Qingzhou Zhang, Qisong Liu, Mingsheng Xie, Chengjie Sun, Wenjun Li, Huacan Lin, Fan Jiang, Tao Wang*, Yun‐Dong Wu*, Zigang Li*, An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide. Angewandte Chemie International Edition 2016, 55 (28), 8013-8017. (IF=11.453)