王璐，1985年生，血液学研究所研究员，博士生导师。2013年在中国科学院大学获得细胞生物学专业博士学位，主要进行造血干细胞发育研究。2019年进入中国医学科学院血液学研究所组建研究团队，主要进行造血干细胞发育及疾病模型相关研究。

我们目前的研究从体内发育、疾病模型和作用机制三个层次深入探讨关键调控因子在血液系统发育和血液疾病发生的作用机理，构建相关疾病模型，以期为相关疾病治疗和药物开发提供理论基础。

1. Li Y#, Tang C#, Liu F, Liu F, Zhu P*, Wang L*. DNA methylation safeguards endothelial-to-hematopoietic transition by repression of Notch signaling. Development. 2022 May 3;dev.200390. doi: 10.1242/dev.200390. (IF=6.862)

2. Lv P^#, Ma D^#, Gao S^#, Zhang Y, Bae YK, Liang G, Gao S, Choi JH, Kim CH, Wang L*, Liu F*. Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells. Stem Cell Reports. 2020 Sep 8;15(3):749-760. (IF=6.032)

3. Lu X, Zhang Y, Liu F*, and Wang L*. Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus During Zebrafish Embryogenesis. J Immunol. 2020, 204(9):2447-2454. (IF=5.422)

4. Liu ZB, Tu HQ, Kang YS, Xue YY, Ma DY, Zhao CT, Li HY, Wang L*, Liu F*. Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nature Commun. 2019, 10(1):1839. (IF=11.878)

5. Yang Y^#, Wang L^#, Han X^#, Yang WL^#, Zhang M^#, Ma HL, Sun BF, Li A, Xia J, Chen J, Heng J, Wu B, Chen YS, Xu JW, Yang X, Yao H, Sun J, Lyu C, Wang HL, Huang Y, Sun YP, Zhao YL, Meng A, Ma J*, Liu F* and Yang YG*. (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Mol Cell. 2019, 75(6):1188-1202. (IF=14.548)

6. Wang L^#, Liu ZB, Lin H, Ma DY, Tao QH, Liu F*. Epigenetic regulation of left-right asymmetry by DNA methylation. EMBO J. 2017, 36(20):2987-97. (IF=10.557)

7. Zhang CX^#, Chen YS^#, Sun BF^#, Wang L^#, Yang Y^#, Ma DY, Lv JH, Heng J, Ding YY, Xue YY, Lu XY, Xiao W, Yang YG*, Liu F*. m6A modulates haematopoietic stem and progenitor cell specification. Nature. 2017, 549(7671):273-76. (IF=40.137)

8. Lv JH^#, Wang L^#, Gao Y, Ding YQ, Liu F*. 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017, 214(2):529-545. (IF=10.790)

9. Wang L^#, Liu TH^#, Xu LJ^#, Gao Y, Wei YL, Duan C, Chen GQ, Lin S, Patient R, Zhang B, Hong DL, Liu F*. Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 2013, 122(3):367-75. (IF=9.775; F1000)

10. Wang L, Zhang PP, Wei YL, Gao Y, Patient R, Liu F*. A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 2011, 118(15):4102-10. (IF=10.558; F1000)