程辉，中国医学科学院血液病医院（血研所）研究员，协和准长聘助理教授，博导。2007年获浙江大学学士学位。2013年获北京协和医学院博士学位。研究方向为造血干细胞及其微环境。以第一/通讯作者（含共同）在Nat Cell Biol、J Clin Invest、J Exp Med、Blood等杂志上发表论文和综述20余篇。国家重点研发计划首席科学家。获国家优青、天津市杰青等人才项目。获国家自然科学奖二等奖。获国内外专利5项。中国生理学会青年委员和天津市血液与再生医学学会理事。

作为最早被应用于临床的成体干细胞，造血干细胞（HSC）功能和分化模式一直以来是研究的热点。我们实验室的研究目标是明确HSC在稳态和疾病状态下的内外调控机制，揭示微环境在其中的变化规律继而对HSC的影响机理，探讨HSC选择性保护的分子机制，以期为白血病的治疗提供新的思路和策略。

1. Yang S.#, Sun G.#, Wu P.#, Chen C.#, Kuang Y., Liu L., Zheng Z., He Y., Gu Q., Lu T., Zhu C., Wang F., Gou F., Yang Z., Zhao X., Yuan S., Yang L., Lu S., Li Y., Lv X., Dong F., Ma Y., Yu J., Ng L., Shi L., Liu J.*, Shi L.*, Cheng T.*, Cheng H.*. WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation. J Exp Med. 2022; 219(4). (IF= 17.579)

2. Wang T.#, Xia C.#, Weng Q., Wang K., Dong Y., Hao S., Dong F., Liu X., Liu L., Geng Y., Guan Y., Du J., Cheng T., Cheng H.*, Wang J*. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica. 2022; 107(1). (IF=11.047)

3. Wang FJ.#, He J.#, Liu S.#, Gao A., Yang L., Sun G., Ding W., Li C., Wang F., Wang X., Zhu P., Hao S., Ma Y.*, Cheng H.*, Yu J.*, Cheng T*. Comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation. Blood. 2021;138(20). (IF=25.476)

4. Yuan S., Sun G., Zhang Y., Dong F., Cheng H.*, Cheng T*. Understanding the ‘SMART’ features of hematopoietic stem cells and beyond. Sci China Life Sci. 2021;64(12). (IF=10.372)

5. Huang D.#, Sun G.#, Hao X.#, He X.#, Zheng Z., Chen C., Yu Z., Xie L., Ma S., Liu L., Zhou B., Cheng H.*, Zheng J.*, and Cheng T*. ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression. J Clin Invest. 2021;131(1). (IF=19.456)

6. Zhang C.#, Xu Z.#, Yang S.#, Sun G.#, Jia L., Zheng Z., Gu Q., Tao W.*, Cheng T.*, Li C.* and Cheng H.*. tagHi-C reveals 3D chromatin architecture dynamics during hematopoiesis. Cell Rep. 2020;32(13). (IF=9.423)

7.   Dong F., Cheng H.*, Ema H.*, Cheng T*. Probing the fate of transplanted hematopoietic stem cells: is the combinational approach "FIT" for purpose? Sci China Life Sci. 2020;63(11):1755-8. (IF=6.037)

8.   Dong F.#, Hao S.#, Zhang S.#, Zhu C.#, Cheng H.#, et al. Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis. Nat Cell Biol. 2020;22(6):630-9. (IF=28.824)

9.   Xia C.#, Wang T.#, Cheng H.#, et al. Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment. Leukemia. 2020;34(9):2375-83. (IF=11.528)

10. Ma S.#, Sun G.#, Yang S., Ju Z.*, Cheng T.*, Cheng H.*. Effects of telomere length on leukemogenesis. Sci China Life Sci. 2020;63(2):308-11. (IF=6.037)