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系统医学研究院

个人简介

马烽,1983年生,籍贯浙江嵊州,医学免疫学博士,系统医学研究院研究员,博士生导师。2002年考入浙江大学化学类专业,2006年获得学士学位。2006-2011年在浙江大学医学免疫学专业攻读博士士学位(硕博连读),从事免疫调控研究。2011年进入UCLA进行博士后研究工作,主要研究抗感染免疫。2016年作为海外高层次引进人才进入系统医学研究院工作,担任研究员。


主要研究方向

宿主抗病毒、抗细菌感染免疫反应的调控,脓毒血症、胰腺炎的致病机制与防治,新型、突发感染性疾病的诊治。


代表性成果

1. Zhu J#, Chen S#, Sun LQ#, Liu S, Bai X, Li D, Zhang F, Qiao Z, Li L, Yao H, Xia Y, Xu P, Jiang X, Chen Z, Yan Y*, Ma F*. 2022. LincRNA-EPS impairs host antiviral immunity by antagonizing viral RNA-PKR interaction. EMBO Rep 23(5): e53937. (IF=9.071)

2. Han Y#, Bai X#, Liu S#, Zhu J#, Zhang F, Xie L, Liu G, Jiang X, Zhang M, Huang Y, Wang J, Li D, Zhang H, He Y, He S, Xia Y, Xu X*, Xu F*, Ma F*. 2022. XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity. J Virol 96(17): e0077422. (IF=6.549)

3. Dou X#, Yu X#, Du S, Han Y, Li L, Zhang H, Yao Y, Du Y, Wang X, Li J, Yang T, Zhang W, Yang C, Ma F*, He S*. 2022. Interferon-mediated repression of miR-324-5p potentiates necroptosis to facilitate antiviral defense. EMBO Rep 23: e54438. (IF=9.071)

4. Yuan Y#, Cai X#, Shen F*, Ma F*. 2021. HPV post-infection microenvironment and cervical cancer. Cancer Lett 497:243-254. (IF=8.680)

5. Li D#, Xie L#, Qiao Z#, Zhu J, Yao H, Qin Y, Yan Y, Chen Z*, Ma F*. 2021. IFI16 Isoforms with Cytoplasmic and Nuclear Locations Play Differential Roles in Recognizing Invaded DNA Viruses. J Immunol 207:2699-2709. (IF=5.422)

6.Li D#, Xie L#, Qiao Z, Mai S, Zhu J, Zhang F, Chen S, Li L, Shen F, Qin Y, Yao H, He S, Ma F*. 2021. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. J Biol Chem 297:100930. (IF=5.157)

7. Li D#, Wu R, Guo W, Xie L, Qiao Z, Chen S, Zhu J, Huang C, Huang J, Chen B, Qin Y, Xu F, Ma F*. 2019. STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production. Cell Rep 29:1249-1260 e4. (IF=8.108)

8. Ma F#, Li B, Yu Y, Iyer SS, Sun M, Cheng G*. 2015. Positive feedback regulation of type I interferon by the interferon-stimulated gene STING. EMBO Rep 16:202-12. (IF=7.739)

9. Ma F#, Liu SY, Razani B, Arora N, Li B, Kagechika H, Tontonoz P, Nunez V, Ricote M, Cheng G*. 2014. Retinoid X receptor alpha attenuates host antiviral response by suppressing type I interferon. Nat Commun 5:5494. (IF=11.470)

10. Ma F#, Xu S, Liu X, Zhang Q, Xu X, Liu M, Hua M, Li N, Yao H, Cao X*. 2011. The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma. Nat Immunol 12:861-9. (IF=26.008, ESI, F1000)