吴爱平，男，1979年生，籍贯江西永新，传染病生物信息学专家，中国医学科学院系统医学研究院研究员，博士生导师。1996年考入南开大学应用物理专业，2000年获得学士学位。2002年在南开大学生物物理专业攻读硕士学位。2005年在中国科学院生物物理研究所生物信息学专业攻读博士学位，2008年留所任助理研究员，2010年为副研究员。2016年在系统医学研究院建立课题组，研究方向为新发突发病毒的分子变异和宿主免疫。

研究领域是传染病生物信息学。围绕流感和新冠等新发突发病毒性传染病，开发基于进化推断和机器学习等方法的新型计算模型，解析病毒的分子进化规律，评估变异导致的免疫逃逸等，进而推动疾病的前瞻性预防控制。

1. Weng S#, Zhou H, Ji C, Li L, Han N, Yang R, Shang J*, Wu A*. Conserved Pattern and Potential Role of Recurrent Deletions in SARS-CoV-2 Evolution. Microbiology Spectrum, 2022,e02191-21. (IF=9.043)

2. Ji C#, Han N, Cheng Y, Shang J, Weng S, Yang R, Zhou H*& Wu A*. Detecting Potentially Adaptive Mutations from the Parallel and Fixed Patterns in SARS-CoV-2 Evolution. Viruses, 2022,14(5), 1087. (IF=5.05)

3.Zhou H#, Cheng Y#, Xu L#, Li J#, Tao C, Ji C, Han N, Yang R, Wu H, Li Y, Wu A*. Genomic evidence for divergent co-infections of co-circulating SARS-CoV-2 lineages. Comput Struct Biotechnol J. 2022; 20:4015-4024. doi: 10.1016/j.csbj.2022.07.042. (IF=6.155)

4. Wu A#, Wang L#, Zhou H#, Ji C, Xia S. Z., Cao Y, Meng J, Ding X, Gold S, Jiang T*, Cheng G*. One year of SARS-CoV-2 evolution. Cell Host & Microbe 2021, https://doi.org/10.1016/j.chom.2021.02.017. 10.1016/j.chom.2021.02.017. (IF=31.316, C100)

5. Shang J#, Han N, Chen Z, Peng Y, Li L, Zhou H, Ji C, Meng J, Jiang T & Wu A*.Compositional diversity and evolutionary pattern of coronavirus accessory proteins. Briefings in Bioinformatics, 2020, 00(00), 1–12. (IF=13.994)

Wu A#, Peng Y#, Huang B#, Ding X#, Wang X, Niu P, Meng J, Zhu Z, Zhang Z, Wang J, Sheng J, Quan L, Xia Z, Tan W*, Cheng G*, Jiang T*. Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host & Microbe 2020, 27(3):325-328. (IF=21.023)

7. Chen Z#, Ji C, Shen Q, Liu W, Qin F. X., Wu A*. Tissue-specific deconvolution of immune cell composition by integrating bulk and single-cell transcriptomes. Bioinformatics 2020, 36(3):819-827. (IF=6.937)

8. Quan L#, Ji C, Ding X, Peng Y, Liu M, Sun J, Jiang T, Wu A*. Cluster-transition determining sites underlying the antigenic evolution of seasonal influenza viruses. Molecular Biology and Evolution 2019, 36(6):1172-1186. (IF=11.602)

9. Chen Z#, Quan L, Huang A, Zhao Q, Yuan Y, Yuan X, Shen Q, Shang J, Ben Y#, Qin FX-F* and Wu A*. seq-ImmuCC: Cell-Centric View of Tissue Transcriptome Measuring Cellular Compositions of Immune Microenvironment from Mouse RNA-Seq Data. Frontiers in Immunology 2018, 9:1286. (IF=5.511)

10. Wu A#, Su C#, Wang D#, Peng Y#, Liu M, Hua S, Li T, Gao F, Tang H, Chen J, Liu X, Shu Y, Peng D*, Jiang T*. Sequential reassortments underlie diverse influenza H7N9 genotypes in China. Cell Host & Microbe 2013, 14(4):446-452. (IF=12.194, C100)