刘芝华，1965年生，籍贯山东，中国医学科学院肿瘤医院副院长，分子肿瘤学国家重点实验室主任。北京大学生科院本科、博士，美国华盛顿州立大学博士后，1996年底加入医科院肿瘤医院工作至今。主要研究工作是肿瘤发生发展的分子机理及转化研究，利用多组学数据鉴定肿瘤驱动基因，对肿瘤进行精确分型，指导临床治疗、发现新型标志物和治疗靶点，阐述关键基因和通路的功能表型和调控机制，在基因表达调控、蛋白翻译后修饰等方面做了系列工作。

主要研究方向为恶性肿瘤发生发展的分子机制及个体化治疗，聚焦食管癌研究，鉴定肿瘤驱动基因，对肿瘤进行精准分型，指导临床治疗；发现早期诊断的分子标志物及肿瘤治疗靶点，阐述关键基因和通路的功能表型和调控机制。

1. Yabing Nan#, Qingyu Luo#, Xiaowei Wu X#, Shi Liu, Pengfei Zhao, Wan Chang, Aiping Zhou, Zhihua Liu*. DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma. Cancer Research. 2022, 82 (16): 2887–2903. (IF=13.312)

2. Jinser Miyoshi#,Zhongxu Zhu#,Aiping Luo#,Shusuke Toden, Xuantong Zhou, Daisuke Izumi, Mitsuro Kanda, Tetsuji Takayama, Iqbal Parker, Minjie Wang, Feng Gao, Ali H Zaidi, Hideo Baba H, Yasuhiro Kodera,Yongping Cui,Xin Wang*,Zhihua Liu*,Ajay Goel*. A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study. Molecular Cancer. 2022, 21(1):44. doi: 10.1186/s12943-022-01507-x. (IF=41.444)

3. Yuanyuan Zhang#, Hongyan Chen#, Hongnan Mo#, Xueda Hu#, Ranran Gao, Yahui Zhao, Baolin Liu, Lijuan Niu, Xiaoying Sun, Xiao Yu, Yong Wang, Qing Chang, Tongyang Gong, Xiuwen Guan, Ting Hu, Tianyi Qian, Binghe Xu,* Fei Ma,* Zemin Zhang,* and Zhihua Liu*. Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer. Cancer Cell.2021 Dec; 39(12):1578–1593. (IF=31.743)

4. Xuantong Zhou#, Min You#, Fuhui Wang, Zhenzhen Wang, Xingfa Gao, Chao Jing, Jiaming Liu, Mengyu Guo, Jiayang Li, Aiping Luo*, Huibiao Liu*, Zhihua Liu*, and Chunying Chen*. Multifunctional Graphdiyne–Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer. Advanced Materials. 2021 Jun;33(24):e2100556. (IF=30.849)

5. Furong Huang#, Hongyan Chen#, Xiaolin Zhu, Tongyang Gong, Xukun Li, William Hankey, Hongyan Wang, Zhong Chen* , Qianben Wang* and Zhihua Liu*. The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3. Cell Research. 2021 Mar;31(3): 362–365. (IF=25.617)

6. Qingyu Luo#, Xiaowei Wu#, Pengfei Zhao#, Yabing Nan, Wan Chang, Xiaolin Zhu, Dan Su, Zhihua Liu*. OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. Advanced Science. 2021 Feb;8: 2002874. (IF=16.806）

7. Yi Li#, Bin Yang, Yanchun Ma, Xiaojun Peng, Zhiyu Wang,Bin Sheng, Zichao Wei, Yongping Cui, Zhihua Liu*. Phosphoproteomics reveals therapeutic targets of esophageal squamous cell carcinoma. Signal Transduction and Targeted Therapy. 2021 Nov;6:381. (IF=18.187)

8. Yongping Cui#, Hongyan Chen#, Ruibin Xi# , Heyang Cui#, Yahui Zhao#, Enwei Xu#, Ting Yan, Xiaomei Lu, Furong Huang, Pengzhou Kong, Yang Li, Xiaolin Zhu, Jiawei Wang, Wenjie Zhu, Jie Wang, Yanchun Ma, Yong Zhou, Shiping Guo, Ling Zhang, Yiqian Liu, Bin Wang, Yanfeng Xi, Ruifang Sun, Xiao Yu, Yuanfang Zhai, Fang Wang, Jian Yang, Bin Yang, Caixia Cheng, Jing Liu, Bin Song, Hongyi Li, Yi Wang, Yingchun Zhang, Xiaolong Cheng, Qimin Zhan*, Yanhong Li *and Zhihua Liu*. Whole Genome Sequencing of 508 Patients Identifies Key Molecular Features Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma. Cell Research. 2020 May;30(10):902-913. (IF=20.507)

9. Qingyu Luo#, Xiaowei Wu#, Wan Chang, Pengfei Zhao, Yabing Nan, Xiaolin Zhu, Jonathan P. Katz, Dan Su, Zhihua Liu*. ARID1A prevents squamous cell carcinoma initiation and chemoresistance by antagonizing pRb/E2F1/c-Myc-mediated cancer stemness. Cell Death & Differentiation. 2020 June; 27:1981-1987. (IF=10.717)

10.Xiaowei Wu#, Qingyu Luo#, Pengfei Zhao, Wan Chang, Yating Wang, Tong Shu, Fang Ding, Bin Li, Zhihua Liu*. MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer. Proc Natl Acad Sci USA. 2019, 116(8):2961-2966. (IF=9.504)