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药用植物研究所

个人简介

孙晓波,1958年生,籍贯吉林延吉,药用植物学家,中国医学科学院药用植物研究所研究员,博士生导师。1978年考入延边医学院(现延边大学)药学专业,1982年获得学士学位。2001年在吉林农业大学作物栽培学与耕作学专业攻读博士学位,从事药用植物研究。1987年升为助理研究员。1992年升为副研究员。1994年升为研究员。


主要研究方向

中药药效物质基础与作用机制研究,质量评价及创新药物开发。将“整合药理学”应用于中药复方研究,快速辨识药效物质,深入阐述其多成分多靶点生物效应的特色,创立的“阿理疗法”是提升中西药合用临床价值的典范。


代表性成果

1. Qin Han, Mengchen Wang, Xi Dong, Fei Wei, Yun Luo*, Xiaobo Sun*. Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential. Front. Immunol. 13(2022):985815. (IF=8.786)

2. Fan Wang, Xueheng Xie, Xiaoyan Xing*, Xiaobo Sun*. Excitatory Synaptic Transmission in Ischemic Stroke: A New Outlet for Classical Neuroprotective Strategies. Int. J. Mol. Sci. 23(2022):9381. (IF=6.208)

3. ShanLu#, YuTian#, YunLuo, XudongXu, WenxiuGe, XiaoboSun*, GuiboSun*. Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury. J Adv Res 29(2021):83-94. (IF=12.822)

4. Ruiying Wang#, Min Wang, Jiahui Zhou, Ziru Dai, Guibo Sun*, Xiaobo Sun*. Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia/reperfusion injury. J Adv Res 34 (2021): 173-186. (IF=12.822)

5. Xuelian Zhang#, Bin Zhang#, Chenyang Zhang, Guibo Sun*, Xiaobo Sun*. Trib1 deficiency causes brown adipose respiratory chain depletion and mitochondrial disorder. Cell Death Dis. 12(2021):1098. (IF=9.705)

6. XiDong#, YunLuo, ShanLu, HanMa, WenchaoZhang, YueZhu, GuiboSun*, XiaoboSun*. Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway. Clin Transl Med 11(2021):e296. (IF=8.554)

7. Weijie Qiang#, Yifei Dai, Xiaoyan Xing*, Xiaobo Sun*. Identification and validation of a prognostic signature and combination drug therapy for immunotherapy of Head and Neck squamous cell carcinoma. Comput. Struct. Biotechnol. J. 19 (2021): 1263-1276. (IF=6.155)

8. Li-Jiao Xu#, Rongchang Chen, Xiaoyu Ma, Yue Zhu, Guibo Sun*, Xiaobo Sun*. Scutellarin protects against myocardial ischemia-reperfusion injury by suppressing NLRP3 inflammasome activation. Phytomedicine 68 (2020): 153169. (IF=5.340)

9. Yun Luo#, Shan Lu, Ye Gao, Ke Yang, Daoshun Wu, Xudong Xu, Guibo Sun*, Xiaobo Sun*. Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy. Aging-US 12(2020): 1704. (IF=5.682)

10. Shuaipeng Lv#, Haitao Liu, Jie Kang, Yun Luo, Ting Gong, Zhengqi Dong, Guibo Sun, Chunnian He, Xiaobo Sun*, Lei Wang*. Palladium-catalyzed enol/enolate directed oxidative annulation: functionalized naphthofuroquinone synthesis and bioactivity evaluation. Chemical communications 55(2019): 14729-14732. (IF=5.996)