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医学实验动物研究所

  • 姓 名:

    秦川

  • 单 位:

    中国医学科学院医学实验动物研究所

  • 教职岗位:

    教授

  • 聘任时间:

    2018-07-01

  • 一级学科:

    基础医学

  • 二级学科:

    病理学与病理生理学

  • 联系方式:

    qinchuan@pumc.edu.cn

  • 导师风采链接:
    http://pumc.teacher.360eol.com/moblic/share?teacherId=3451

个人简介

秦川,籍贯山东,实验病理学家,医学实验动物研究所教授,博士生导师,国家级重大人才项目(教育部)入选者。长期致力于人类疾病动物模型研制和应用研究,以第一作者或通讯作者在Cell,Science,Nature等杂志发表文章290余篇,授权专利21项,主编专著17部、教材5部,主持建立标准164项,主持重大科技专项、863、国家自然基金等国家级课题20余项。获国家科学技术进步奖二等奖、全国创新争先奖、全国三八红旗手标兵等国家级荣誉。享受国务院政府特殊津贴。


主要研究方向

传染性疾病如COVID-19、甲流和禽流感等突发再发传染病动物模型的建立与应用,神经退行性疾病的比较医学研究,包括新模型的研制,应用模型进行机制研究与治疗措施的评价等。


代表性成果

1. Wang K#, Jia Z#, Bao L#, Wang L#, Cao L#, Chi H#, Hu Y#, Li Q#, Zhou Y#, Jiang Y, Zhu Q, Deng Y, Liu P, Wang N, Wang L, Liu M, Li Y, Zhu B, Fan K, Fu W, Yang P, Pei X, Cui Z, Qin L, Ge P, Wu J, Liu S, Chen Y, Huang W, Wang Q*, Qin CF*, Wang Y*, Qin C*, Wang X*. Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants. Nature. 2022 Mar;603(7903):919-925. (IF=69.504)

2. Guo Q#, Zhao Y#, Li J#, Liu J#, Yang X#, Guo X, Kuang M, Xia H, Zhang Z, Cao L, Luo Y, Bao L, Wang X, Wei X, Deng W, Wang N, Chen L, Chen J, Zhu H, Gao R, Qin C*, Wang X*, You F*. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host Microbe. 2021 Feb 10;29(2):222-235.e4. (IF=31.316, C100)

3. Du S#, Cao Y#, Zhu Q#, Yu P#, Qi F#, Wang G, Du X, Bao L, Deng W, Zhu H, Liu J, Nie J, Zheng Y, Liang H, Liu R, Gong S, Xu H, Yisimayi A, Lv Q, Wang B, He R, Han Y, Zhao W, Bai Y, Qu Y, Gao X, Ji C, Wang Q, Gao N, Huang W, Wang Y, Xie XS*, Su XD*, Xiao J*, Qin C*. Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy. Cell. 2020 Nov 12;183(4):1013-1023.e13. (IF=41.582, C100)

4. Wang H#, Zhang Y#, Huang B#, Deng W#, Quan Y#, Wang W#, Xu W#, Zhao Y, Li N, Zhang J, Liang H, Bao L, Xu Y, Ding L, Zhou W, Gao H, Liu J, Niu P, Zhao L, Zhen W, Fu H, Yu S, Zhang Z, Xu G, Li C*, Lou Z*, Xu M*, Qin C*, Wu G*, Gao GF*, Tan W*, Yang X*. Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2. Cell. 2020 Aug 6;182(3):713-721.e9.  (IF=41.582, C100)

5. Deng W#, Bao L#, Liu J#, Xiao C#, Liu J#, Xue J#, Lv Q#, Qi F, Gao H, Yu P, Xu Y, Qu Y, Li F, Xiang Z, Yu H, Gong S, Liu M, Wang G, Wang S, Song Z, Liu Y, Zhao W, Han Y, Zhao L, Liu X, Wei Q, Qin C*. Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques. Science. 2020 Aug 14;369(6505):818-823. (IF=63.714, C100)

6. Dai L#*, Zheng T#, Xu K#, Han Y#, Xu L#, Huang E, An Y, Cheng Y, Li S, Liu M, Yang M, Li Y, Cheng H, Yuan Y, Zhang W, Ke C, Wong G, Qi J, Qin C*, Yan J*, Gao GF*. A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS. Cell. 2020 Aug 6;182(3):722-733.e11.  (IF=41.582, C100)

7. Cao Y#, Su B#, Guo X#, Sun W#, Deng Y#, Bao L#, Zhu Q#, Zhang X, Zheng Y, Geng C, Chai X, He R, Li X, Lv Q, Zhu H, Deng W, Xu Y, Wang Y, Qiao L, Tan Y, Song L, Wang G, Du X, Gao N, Liu J, Xiao J, Su XD, Du Z, Feng Y, Qin C*, Qin C*, Jin R*, Xie XS*. Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells. Cell. 2020 Jul 9;182(1):73-84.e16. (IF=41.582, C100)

8. Gao Q#, Bao L#, Mao H#, Wang L#, Xu K#, Yang M, Li Y, Zhu L, Wang N, Lv Z, Gao H, Ge X, Kan B, Hu Y, Liu J, Cai F, Jiang D, Yin Y, Qin C, Li J, Gong X, Lou X, Shi W, Wu D, Zhang H, Zhu L, Deng W, Li Y, Lu J*, Li C*, Wang X*, Yin W*, Zhang Y*, Qin C*. Development of an inactivated vaccine candidate for SARS-CoV-2. Science. 2020 Jul 3;369(6499):77-81. (IF=63.714, C100)

9. Bao L#, Deng W#, Huang B#, Gao H#, Liu J#, Ren L, Wei Q, Yu P, Xu Y, Qi F, Qu Y, Li F, Lv Q, Wang W, Xue J, Gong S, Liu M, Wang G, Wang S, Song Z, Zhao L, Liu P, Zhao L, Ye F, Wang H, Zhou W, Zhu N, Zhen W, Yu H, Zhang X, Guo L, Chen L, Wang C, Wang Y, Wang X, Xiao Y, Sun Q, Liu H, Zhu F, Ma C, Yan L, Yang M, Han J, Xu W, Tan W, Peng X, Jin Q, Wu G*, Qin C*. The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. Nature. 2020 Jul;583(7818):830-833. (IF=49.96, C100)

10. Yang W#, Liu Y, Tu Z, Xiao C, Yan S, Ma X, Guo X, Chen X, Yin P, Yang Z, Yang S, Jiang T, Li S*, Qin C*, Li XJ*. CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys. Cell Res. 2019 Apr;29(4):334-336.(IF=20.507)