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药物研究所

个人简介

于德泉,1932年生,籍贯山东蓬莱,天然药物化学家,中国工程院院士,药物研究所研究员,博士生导师。1952年考入北京医学院药学系药物化学专业,1956年获得学士学位。


主要研究方向

于德泉教授是我国著名的天然药物化学专家,中国工程院院士,从事天然药物化学研究工作60余年,完成了百余种中草药化学成分研究,首次发现过氧键为抗疟有效基团。参与主持了国家攻关项目“人工麝香”研究,该项目的投产创造了可观的经济效益,部分缓解了天然麝香紧缺问题,获国家科技进步一等奖(2015年)。系统地研究了三种藁本植物化学成分及其药理作用,发现四种具明显保肝和免疫抑制成分,完成全合成及构效关系研究。完成了秦艽、灵芝、连翘等常用中药化学成分基础研究,获得卫生部科技进步二等奖。在番荔枝科植物抗癌有效成分的研究中,发现70多种结构新颖的化合物,其中50多种具抗癌活性,该研究获卫生部科技进步二等奖。


代表性成果

1. Bioactive bisbenzylisoquinoline alkaloids from the roots of Stephania tetrandra, Renzhong Wang, Yanfei Liu, Guoru Shi, Jie Zhou, Jiayuan Li, Li, Li, Jiqiao Yuan, Xuyu Li,  Dequan Yu*, Bioorganic Chemistry, 2020, 98, 103697.

2. Iridal-Type Triterpenoids with a Cyclopentane Unit from the Rhizomes of Belamcanda chinensis, Jiayuan Li, Gang, Yanfei Liu, Zhenpeng Mai, Renzhong Wang, Dequan Yu*, J. Nat. Prod. 2019, 82, 1759-1767.

3. Nine new compounds form the whole plants of Rehmannia henryi, Jie Zhou, Guoru Shi, Yanfei Liu, Ruoyun Chen, Dequan Yu*, J. Asian Nat. Prod. Res. 2019, 21 (5) : 399-408.

4. Five new iridoids form the whole plants of Rehmannia henryi, Jie Zhou, Guoru Shi, Yanfei Liu, Ruoyun Chen, Dequan Yu*, J. Asian Nat. Prod. Res, 2019, 21 (8) : 727-734.

5. Heliojatrones A and B, two jatrophane-derived diterpenoids with a 5/10 fused-ring skeleton from Euphorbia helioscopia: structural elucidation and biomimetic conversion, Zhenpeng Mai, Gang Ni, Yanfei Liu, Li Li, Jiayuan Li, Dequan Yu*, Organic Letters, 2018, 20: 3124-3127.

6. Secoheliosphanes A and B and secoheliospholane A, three diterpenoids with unusual seco-jatrophane and seco-jatropholane skeletons from Euphorbia helioscopia, Zhenpeng Mai, Gang Ni, Yanfei Liu, Li Li, Jiayuan Li, Dequan Yu*, The Journal of Organic Chemistry 2018, 83 (1): 167-173.

7. Helioscopianoids A‒Q, bioactive jatrophane diterpenoids esters from Euphorbia helioscopia, Zhenpeng Mai, Gang Ni, Yanfei Liu, Li Li, Naihong Chen, Dequan Yu*, Acta Pharmaceutica Sinica B, 2018, 8(5): 805-817.

8. Four new compounds from the rhizome of Aristolochia championii, Xin Wang, Guoru Shi, Yanfei Liu, Ruoyun Chen, Dequan Yu*, J. Asian Nat. Prod. Res, 2017, 19 (2): 114-120.

9. Polycycloiridals with a Cyclopentane Ring from Iris tectorum, Chunlei Zhang, Yanfei Liu, Yan Wang, Dong Liang, Zhibo Jiang, Li Li, Zhiyou Hao, Huan Luo, Guoru Shi, Ruoyun Chen, Zhengyu Cao, Dequan Yu*, J. Nat. Prod. 2017, 80, 156-161.

10. Polycycloiridals A−D, Four Iridal-Type Triterpenoids with an α-Terpineol Moiety from Iris tectorum, Chunlei Zhang, Zhiyou Hao, Yanfei Liu, Yan Wang, Guoru Shi, Zhibo Jiang, Ruoyun Chen, Zhengyu Cao, Dequan Yu*, Organic Letters, 2015, 17 5686-5689.