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血液病医院

个人简介

程涛,1963年生,籍贯江苏,血液学与干细胞生物学家,中国医学科学院北京协和医学院长聘教授,博士生导师。1989年于第二军医大学获得医学硕士学位,随后在第二军医大学附属长海医院历任住院医师和主治医师。1993-1997年在美国希普癌症研究中心和马萨诸塞州总医院接受了博士后培训。1998年被哈佛大学聘为讲师,2001年成为助理教授。2001年开始在美国匹兹堡大学医学院历任助理教授(终聘系列)、副教授(2006年)、正教授(2010年)。2007年全职回国。


主要研究方向

主要从临床需求出发,围绕造血干细胞数量、质量以及微环境调控进行了长期而系统的研究,开拓损伤与疾病环境下造血干细胞生物学研究新领域,提出造血再生新理论,建立干细胞应用和基因治疗新技术。阐明了在白血病环境下正常造血干、祖细胞与恶性细胞的竞争规律及部分调控机制。


代表性成果

1. Zhang Y#, Wang S#, Zhang J#, Liu C#, Li X#, Guo W, Duan Y, Chen X, Zong S, Zheng J, Wu Y, Chen X, Cheng X, Chang Y, Wang Y, Ding F, Yang W, Chen X, Guo Y, Zhang L, Chen Y, Zou Y, Zhu X*, Gu J*, Cheng T*. Elucidating minimal residual disease of paediatric B-cell acute lymphoblastic leukaemia by single-cell analysis. Nat Cell Biol. 2022 Feb;24(2):242-252. (IF=28.824)

2. Hu LP#, Yin XX#, Zhang YW#, Pang AM#, Xie XW, Yang SD, Zhu CY, Li YP, Zhang B, Huang YJ, Tian YH, Mei Wang M, Cao WB, Chen SL, Ma SH, Dong F, Hao S, Feng SZ, Ru YX, Cheng H, Jiang EL*, Cheng T*. Radiation-induced bystander effects impair transplanted human hematopoietic stem cells via oxidative DNA damage. Blood. 2021 Jun 17;137(24):3339-3350. (IF=23.629)

3. Wang FJ#, He JH#, Liu SQ#, Gao A, Yang L, Sun GH, Ding WQ, Li CY, Gou FL, He MM, Wang F, Wang XS, Zhao XN, Zhu P, Hao S, Ma YN*, Cheng H*, Yu J*, Cheng T*. Comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation. Blood. 2021 Nov 18;138(20):1939-1952. (IF=23.629)

4. Tong J#, Sun T#, Ma S#, Zhao Y#, Ju M#, Gao Y, Zhu P, Tan P, Fu R, Zhang A, Wang D, Wang D, Xiao Z, Zhou J, Yang R, Loughran SJ, Li J, Green AR, Bresnick EH, Wang D*, Cheng T*, Zhang L*, Shi L*. Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms. Cell Stem Cell. 2021 Mar 4;28(3):502-513.e6. (IF=24.633)

5. Dong F#, Hao S#, Zhang S#, Zhu C#, Cheng H#, Yang Z, Hamey FK, Wang X, Gao A, Wang F, Gao Y, Dong J, Wang C, Wang J, Lan Y, Liu B, Ema H, Tang F, Göttgens B*, Zhu P*, Cheng T*. Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis. Nat Cell Biol. 2020 Jun;22(6):630-639. (IF=28.824, F1000)

6. Zhu X#, He F#, Zeng H#, Ling S#, Chen A#, Wang Y, Yan X, Wei W, Pang Y, Cheng H, Hua C, Zhang Y, Yang X, Lu X, Cao L, Hao L, Dong L, Zou W, Wu J, Li X, Zheng S, Yan J, Zhou J, Zhang L, Mi S, Wang X, Zhang L, Zou Y, Chen Y, Geng Z, Wang J, Zhou J, Liu X, Wang J, Yuan W, Huang G*, Cheng T*, Wang QF*. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet. 2014 Mar;46(3):287-93. (IF=38.33, C100)

7. Sung L#, Gao S#, Shen H, Yu H, Song Y, Smith S, Chang C, Inoue, Kuo L, Lian J, Li A, Tian X, Tuck D, Weissman S, Yang X*, Cheng T*. Differentiated cells are more efficient than adult stem cells as donors for cloning by somatic cell nuclear transfer. Nat Genet. 2006 Nov;38(11):1323-8. (IF=38.33)

8. Yuan Y#, Shen H#, Franklin DS, Scadden DT and Cheng T*. In Vivo Self-renewing divisions of hematopoietic stem cells in vivo are increased in the absence of the early G1-phase inhibitor, p18INK4c. Nat Cell Biol. 2004 May; 6(5): 436-42. (IF=20.042, C100)

9. Cheng T#*, Rodrigues N, Dombkowski D, Stier S and Scadden DT*. Stem cell repopulation efficiency but not pool size is governed by p27(kip1). Nat Med. 2000; 6 1236-40. (IF=36.13, C100)

10. Cheng T#, Rodrigues N, Shen H, Yong-guang Yang, Dombkowski D, Sykes M and Scadden DT*. Hematopoietic stem cell quiescence in vivo is maintained by p21. Science 2000; 287: 1804-1808. (IF=41.846, C100)