张抒扬，1963年生，现任中国医学科学院北京协和医院（临床医学研究所）院（所）长、党委副书记，中国医学科学院北京协和医学院副院校长、党委常委（兼）。心血管内科学教授，主任医师，博士生导师。1980年考入北京医科大学医学专业，获学士学位。1986年在中国协和医科大学内科学心血管学专业攻读博士学位，从事临床医学专业研究。1995年进入美国路易斯安那州新奥尔良市AltonOchsner心血管研究院心脏科进行博士后研究工作，主要研究心血管及疑难罕见疾病的发病机制、临床诊疗及新药研发。1999年升为副主任医师。2005年升为主任医师。

冠心病、高血压、血脂异常等慢病综合管理与防治；心肌病和各种原因导致的心力衰竭的早期诊断与个体化治疗；心血管系统以及全身疾病导致的复杂疑难及危险重症的分子机制、临床诊疗及新药研发；新型冠状病毒致病机制、临床诊疗路径与药物研发。

1. Yang Zhang^#, Yicong Ye^#, Xiaoqiang Tang^#, Hui Wang^#, Toshiko Tanaka, Ran Tian , Xufei Yang, Lun Wang, Ying Xiao, Xiaomin Hu , Ye Jin, Haiyu Pang, Tian Du, Honghong Liu, Lihong Sun, Shuo Xiao, Ruijia Dong, Luigi Ferrucci, Zhuang Tian*, Shuyang Zhang*. CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure. J Exp Med.2022;219(8): e20200418. (IF=14.31)

2. Jie Ma, Jia liu, Dunqin Gao, Xiao Li, Qiyu Zhang, Luye Lv, Yujie Wang, Jun Li, Yunping Zhu, Zhihong Wu, Hengrui Hu, Yufeng Li, Longda Ma, Qian Liu, Zhihong Hu, Shuyang Zhang,* Yiwu Zhou,* Manli Wang,* and Ling Leng*. Establishment of Human Pluripotent Stem Cell-Derived Skin Organoids Enabled Pathophysiological Model of SARS-CoV-2 Infection. Adv Sci (Weinh). 2022;9(7):e2104192. (IF=16.81)

3. Xiao-Hong Yao, Tao Luo, Yu Shi, Zhi-Cheng He, Rui Tang, Pei-Pei Zhang, Jun Cai , Xiang-Dong Zhou, Dong-Po Jiang, Xiao-Chun Fei, Xue-Quan Huang, Lei Zhao, Heng Zhang, Hai-Bo Wu, Yong Ren, Zhen-Hua Liu, Hua-Rong Zhang, Cong Chen, Wen-Juan Fu1 , Heng Li, Xin-Yi Xia, Rong Chen, Yan Wang, Xin-Dong Liu, Chang-Lin Yin, Ze-Xuan Yan, Juan Wang, Rui Jing, Tai-Sheng Li, Wei-Qin Li, Chao-Fu Wang, Yan-Qing Ding, Qing Mao, Ding-Yu Zhang, Shu-Yang Zhang, Yi-Fang Ping and Xiu-Wu Bian . A cohort autopsy study defines COVID-19 systemic pathogenesis. Cell Res. 2021;31(8):836-846. (IF=25.62)

4. Qing Wu, Lulu Sun, Xiaomin Hu, Xuemei Wang, Feng Xu, Bo Chen, Xianyi Liang, Jialin Xia, Pengcheng Wang, Daisuke Aibara, Shaofei Zhang,Guangyi Zeng, Chuyu Yun, Yu Yan,Yicheng Zhu, Michael Bustin, Shuyang Zhang, Frank J. Gonzalez, and Changtao Jiang. Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis. J Clin Invest. 2021;131(9):e142865. (IF=14.81)

5. Wanchao Yin, Xiaodong Luan, Zhihai Li, Ziwei Zhou1, Qingxing Wang, Minqi Gao, Xiaoxi Wang , Fulai Zhou , Jingjing Shi , Erli You , Mingliang Liu , Qingxia Wang, Yi Jiang, Hualiang Jiang, Gengfu Xiao , Leike Zhang*, Xuekui Yu*, Shuyang Zhang* and H. Eric Xu*. Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. Nat Struct Mol Biol. 2021;28(3):319-325.  (IF=15.369, ESI)

6. Yan Zhang, Meng Xiao, Shulan Zhang, Peng Xia, Wei Cao, Wei Jiang, Huan Chen, Xin Ding, Hua Zhao, Hongmin Zhang, Chunyao Wang, Jing Zhao, Xuefeng Sun, Ran Tian, Wei Wu, Dong Wu, Jie Ma,  Yu Chen, Dong Zhang, Jing Xie, Xiaowei Yan, Xiang Zhou, Zhengyin Liu, Jinglan Wang, Bin Du, Yan Qin, Peng Gao, Xuzhen Qin,  Yingchun Xu, Wen Zhang, Taisheng Li, Fengchun Zhang, Yongqiang Zhao, Yongzhe Li, Shuyang Zhang, Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19. N Engl J Med. 2020;382(17):e38. (IF=91.25, C100, F1000)

7. Yang-Yang He, Yi Yan, Xin Jiang, Jun-Han Zhao, Zhe Wang, Tao Wu, Yong Wang , Shan-Shan Guo , Jue Ye, Tian-Yu Lian, Xi-Qi Xu, Jin-Lan Zhang , Kai Sun , Fu-Hua Peng, Yu-Ping Zhou , Yi-Min Mao, Xue Zhang, Ji-Wang Chen , Shu-Yang Zhang and Zhi-Cheng Jing. Spermine promotes pulmonary vascular remodelling and its synthase is a therapeutic target for pulmonary arterial hypertension. Eur Respir J. 2020;56(5):2000522. Published 2020 Nov 5. (IF=16.67)

8. Wanchao Yin^*, Chunyou Mao^*, Xiaodong Luan^*, Dan-Dan Shen^*, Qingya Shen^*, Haixia Su^*, Xiaoxi Wang , Fulai Zhou , Wenfeng Zhao , Minqi Gao , Shenghai Chang, Yuan-Chao Xie, Guanghui Tian , He-Wei Jiang, Sheng-Ce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shuyang Zhang, Yan Zhang, H. Eric Xu. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science. 2020;368(6498):1499-1504. (IF=47.73, F1000, C100, ESI)

9. Shuyang Zhang, Limeng Chen, Zongjiu Zhang, Yupei Zhao. Orphan drug development in China: progress and challenges. Lancet. 2019;394(10204):1127-1128. (IF=79.32)

10. Honghong Liu , Xi Chen , Xiaomin Hu , Haitao Niu , Ran Tian , Hui Wang , Haiyu Pang , Lingjuan Jiang, Bintao Qiu , Xiuting Chen , Yang Zhang , Yiyangzi Ma , Si Tang , Hanyu Li , Siqin Feng , Shuyang Zhang^* and Chenhong Zhang^* . Alterations in the gut microbiome and metabolism with coronary artery disease severity. Microbiome. 2019;7(1):68. Published 2019 Apr 26. (IF=14.65, C100, ESI)