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基础医学研究所

  • 姓 名:

    赵春华

  • 单 位:

    中国医学科学院基础医学研究所

  • 教职岗位:

    教授

  • 聘任时间:

    2018-07-01

  • 一级学科:

    生物学

  • 二级学科:

    细胞生物学

  • 联系方式:

    zhaochunhua@vip.163.com

  • 导师风采链接:
    http://pumc.teacher.360eol.com/teacherBasic/teacherInfo

个人简介

赵春华,医学博士、博士生导师。国际衰老和疾病协会主席。北京协和医学院长聘教授,中国医学科学院组织工程研究中心主任,干细胞新药研发及临床转化研究北京市重点实验室主任。致力于干细胞生物学、药学与临床研究30余年,国家973计划、863计划、国家重点研发计划等项目首席科学家,国际上提出了“亚全能干细胞学说”概念和“间充质干细胞系统”概念,建立了集成体干细胞基础理论、关键科学技术、临床试验治疗研究为一转化医学体系。


主要研究方向

致力于干细胞生物学、药学与临床研究30余年,国际上提出了“亚全能干细胞学说”概念和“间充质干细胞系统”概念,获国家药监局(SFDA)首个干细胞新药临床批件,实践了干细胞新制品临床安全有效治疗疾病。建立了集成体干细胞基础理论、关键科学技术、临床试验治疗研究为一转化医学体系。


代表性成果

1. Pei Wang#, Longfei Tang , Bohui Zhou , Liangfen Cheng , Robert Chunhua Zhao*Juan Zhang*.Analytical methods for the detection of PD-1/PD-L1 and other molecules related to immune checkpoints.Trends in Analytical Chemistry, 146 (2022) 116505. (IF=14.9)

2. Li X #, Sun Z #, Peng G #, Xiao Y, Guo J, Wu B, Li X, Zhou W, Li J, Li Z, Bai C, Zhao L*, Han Q*, Robert Chunhua Zhao*, Wang X*. Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer.Theranostics. 2022 Jan 1;12(2):620-638. (IF=11.556)

3. Zhu R#, Yan T#, Feng Y#, Liu Y#, Cao H, Peng G, Yang Y, Xu Z, Liu J, Hou W, Wang X, Li Z, Deng L, Wang S, Li J, Han Q, Li H, Shan G, Cao Y, An X, Yan J, Zhang Z, Li H, Qu X, Zhu J, Zhou S, Wang J, Zhang F, Gao J, Jin R*, Xu D, Ma YQ, Huang T, Peng S, Zheng Z, Stambler I, Gilson E, Lim LW, Moskalev A, Cano A, Chakrabarti S, Ulfhake B, Su H, Xu H, Xu S, Wei F, Brown-Borg HM, Min KJ, Ellison-Hughes G, Caruso C, Jin K*, Zhao RC*. Mesenchymal stem cell treatment improves outcome of COVID19 patients via multiple immunomodulatory mechanisms. Cell Res. 2021 Oct 26:1-19. (IF=46.2953)

4. Xian Xiao#, Meiqian Xu, Hongliang Yu, Liping Wang, Xiaoxia Li, Janusz Rak, Shihua Wang* and Robert Chunhua Zhao*. Mesenchymal stem cell derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src signal transduction and targeted therapy. Signal Transduct Target Ther. 2021 Oct 22;6(1):354. (IF= 38.1027)

5. Leng Z#, Zhu R#, Hou W#, Feng Y#, Yang Y, Han Q, Shan G, Meng F, Du D, Wang S, Fan J, Wang W, Deng L, Shi H, Li H, Hu Z, Zhang F, Gao J, Liu H*, Li X, Zhao Y, Yin K, He X, Gao Z, Wang Y, Yang B, Jin R*, Stambler I, Lim LW, Su H, Moskalev A, Cano A, Chakrabarti S, Min KJ, Ellison-Hughes G, Caruso C, Jin K*, Zhao RC*. Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia. Aging Dis. 2020 April: 11(2):216-228. (IF=9.9675, ESI, C100, R)

6. Li J#, Hao Y#, Mao W#, Xue X#, Xu P, Liu L, Yuan J, Zhang D, Li N, Chen H, Zhao L, Sun Z*, Luo J*, Chen R*, Zhao RC*.LincK contributes to breast tumorigenesis by promoting proliferation and epithelial-to-mesenchymal transition.J Hematol Oncol. 2019 Feb 22;12(1):19. (IF=11.059)

7. Xingxia Liu#, Xuebin Qu, Yuan Chen, Lianming Liao, Kai Cheng, Changshun Shao, Martin Zenke, Armand Keating, Robert C H Zhao*. Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation. J Immunol. 2012 Aug 1;189(3):1182-92. (IF=5.5199, F1000)

8. Zhang B#, Liu R, Shi D, Liu X, Chen Y, Dou X, Zhu X, Lu C, Liang W, Liao L, Zenke M*, Robert C H Zhao*. Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2 dependent regulatory dendritic cell population. Blood. 2009 Jan 1;113(1):46-57. (IF=10.558, C100)

9. Qiao L#, Xu Z, Zhao T, Zhao Z, Shi M, Zhao RC*, Ye L*, Zhang X*. Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Res. 2008 Apr;18(4):500-7. (IF=9.417, C100)

10. Fang B#, Zheng C#, Liao L, Han Q, Sun Z, Jiang X, Zhao RC*. Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics. Blood. 2005 Apr 1;105(7):2733-40. (IF=10.558)